info@shantani.com | Tel: +91-20-64103918, +91-20-64009991


 

What Do We Offer?

Shantani offers an array of chemical proteomics services for small molecule target deconvolution. This includes a combination of proprietary and publicly-known methods for target ID and validation, such as:

A comparison of these and related target ID technologies is available below. Using our deep understanding of chemical proteomics, we will help you identify the most suitable method(s) for your drug discovery project. Click here to download PDF.



How Do We Work With You?

For each engagement, Shantani provides a clear breakup of the costs and tasks involved in the project. If we together conclude that you are best positioned to undertake particular tasks, Shantani will consider a collaborative engagement model. This further lowers the cost of target identification, validation and MoA studies, by a) optimal use of resources and b) faster GO / NO-GO decision-making.

Steps Activity Outcome
Step
1
Client becomes aware of Shantani's services Client calls / emails Shantani for more information
Step
2
Client & Shantani discuss how the client's drug discovery program can benefit from Shantani's services related to target ID, validation, MoA, etc. Client & Shantani sign CDA (if relevant).

Shantani shares technical & workflow information, while client shares project information.
Step
3
Client & Shantani discuss & agree on the most suitable technology to use. Shantani shares standard business proposal with scope, milestones, deliverables and costs.
Step
4
Client conducts internal review of Shantani's proposal, and continues refinement of project scope. Shantani shares a revised, customized business proposal - based on client feedback.
Step
5
Client & Shantani discuss, negotiate & agree on final proposal T&Cs. Client obtains internal management approvals & issues a P.O. to Shantani.


How Do We Execute Projects?

Before starting each project, Shantani lays out the experiment plans and client appraisal timelines. While Shantani's expertise in chemical proteomics helps identify the technology to use and the righful target(s), we firmly believe that the client is the one who can best use such '-omics' experiments to truly understand the MoA of your molecule. Hence, we send frequent updates to our clients as targets get identified & validated.

Week SCLS UPT TBB COMP
Project Preparation# SAR analysis + Derivatization of bait molecule. Preparation of sufficient amount of cell lysate. SAR analysis + Derivatization of bait molecule.  
Week
0
Client gives Shantani the go-ahead to start project work, pays the project initiation fee*. Shantani initiates project work.
Week
1^
Preparation of SCLS probes specific to bait molecule Preparation & characterization of affinity matrix specific to bait molecule Preparation of probes specific to bait molecule Structure and function based data mining, using proprietary computational workflow
Week
2^
Purification & characterization of SCLS probes Identification of target using mass spectrometry Identification of target using mass spectrometry Listing of putative targets & 'in silico' validation of targets
Week
3^
Functional activity assay of SCLS probes Data analysis, target deconvolution and writing the report. Data analysis, target deconvolution and writing the report. Data analysis, target deconvolution and writing the report.
Week
4^
Target capture experiments from specific sub-cellular location      
Week
5^
Identification of target using mass spectrometry      
Week
6^
Data analysis, target deconvolution and writing the report.      
# Project preparation work (SAR analysis, derivatization, cell lysate prep) can be done by Client or Shantani (by paying a separate fee).
* Remaining fees to be paid upon completion of milestones, as defined in project scope.
^ Actual time taken may be longer if the 'bait/test' molecule and its related assays are complex.